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Sickle-cell Disease

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❶History Hemoglobinopathy is the study of genetic abnormalities that involves the globin chains of hemoglobin, the red component in the blood that carries oxygen. The acuteness of signs and symptoms differs from individual to individual.

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Ask for a quote. It took Noel nine years to succumb, presumably as a consequence of his condition. A researcher named Haln first coined the term "sickle cell" but it was V. Emmel who documented that the sickle cell trait could be present in healthy individuals without developing anemia.

By the s, it was established that the sickle cell was a result of abnormal hemoglobin but not the mechanism that led to the abnormality. In the s, American scientist Vernon Ingram isolated the culprit, an amino acid called valine, which took the place of glutamic in the beta globin chain of hemoglobin.

It may sound a trifling change, but it has had a profound impact on those who have it. Sickle cell is a genetic disorder that turns red blood cells, which should be round and flexible into stiff and sickle-shaped cells, which is why it is called sickle cell. This is due to mutations in the beta-hemoglobin HBB gene.

Because they are inflexible, it is unable to travel smoothly in the blood vessels, bunching up and slowing the flow, preventing the efficient delivery of oxygen.

This results in pain, organ damage and infection. The anemia results from the early death of these cells with a life span of 20 days as opposed to the normal days for normal cells. The body is unable to keep up the supply of new cells. It is transmitted via autosomal recessive inheritance, meaning it is passed from generation to generation and may present without any symptoms unless both parents carry the genes. In order for sickle cell trait to manifest into sickle cell anemia, a person must have two defective genes, one from each parent.

sickle cell anemia essay

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Sickle cell anemia occurs when a person inherits two sickle cell gene, one from each parent, that cause the red blood cells to change and become crescent shaped. The underlying problem involves hemoglobin, a component of the red blood cells.

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B- Sickle cell anemia: A person with sickle cell anemia has most or all of the normal hemoglobin replaced with the sickle hemoglobin. It is the most common and most severe form of the sickle cell variations." These individuals suffer from a variety of complications due to the shape and thickness of the sickle cells. Essay The sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell have red blood cells that have mostly hemoglobin's, Sometimes these red blood cells become sickle-shaped or crescent shaped and have trouble going through small blood vessels.

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Sickle Cell Anemia Essay Words | 5 Pages. Sickle cell disease is a hereditary hemoglobin defect that occurs in people of African and Mediterranean decent. “First identified in by a hospital intern, sickle cell disease became, more than forty years later, the first disease found to . Abstract Sickle cell anemia is a group of inherited red blood cell disorders. Normal red blood cells are round like doughnuts, and they move through small tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat.